Platelet rich plasma (PRP) is exactly what the name suggests. The substance is a by-product of blood (plasma) that is rich in platelets. Until now, its use has been confined to the hospital setting. This was due mainly to the cost of separating the platelets from the blood and the large amount of blood (one unit) needed to produce a suitable quantity of platelets. New technology permits Drs. Fraser and Michaels to harvest and produce a sufficient quantity of platelets from only 55 cc of blood drawn from your vein while you are having outpatient surgery in our state of the art facility.
PRP permits the body to take advantage of the normal healing pathways at a greatly accelerated rate. During the healing process, the body rushes many cells and cell-types to the wound in order to initiate the healing process. One of those cell types is platelets. Platelets perform many functions, including formation of a blood clot and release of growth factors (GF) into the wound. These growth factors (platelet derived growth factor PGDF, transforming growth factor beta TGF, and insulin-like growth factor ILGF) function to assist the body in repairing itself by stimulating stem cells to regenerate new tissue. The more growth factors released and sequestered into the wound, the more your stem cells stimulate your body to produce new host tissue. Thus, one can easily see that PRP permits the body to heal faster and more efficiently.
A subfamily of TGF, is bone morphogenic protein (BMP). BMP has been shown to induce the formation of new bone in research studies in animals and humans. This is of great significance to Drs. Fraser and Michaels who place dental implants. By adding PRP, and thus BMP, to the implant site with bone graft particles, Drs. Fraser and Michaels can now grow bone more predictably and faster than ever before.
Bone grafting for dental implants. This includes onlay and inlay grafts, sinus lift procedures, ridge augmentation procedures, and closure of cleft, lip, and palate defects.
Repair of bone defects creating by removal of teeth or small cysts.
Repair of fistulas between the sinus cavity and mouth.
Safety: PRP is a by-product of the patient's own blood, therefore, disease transmission is not an issue.
Convenience: PRP can be generated in Drs. Fraser and Michaels office while the patient is undergoing an outpatient surgical procedure, such as placement of dental implants.
Faster healing: The supersaturation of the wound with PRP, and thus growth factors, produces an increase of tissue synthesis and thus faster tissue regeneration.
Cost effectiveness: Since PRP harvesting is done with only 55 cc of blood in Drs. Fraser and Michaels office, the patient need not incur the expense of the harvesting procedure in hospital or at the blood bank.
Ease of use: PRP is easy to handle and actually improves the ease of application of bone substitute materials and bone grafting products by making them more gel-like.
Is PRP safe? Yes. During the outpatient surgical procedure a small amount of your own blood is drawn out through your IV. This blood is then placed in the PRP centrifuge machine and spun down. In less than 15 minutes, the PRP is formed and ready to use.
Should PRP be used in all bone-grafting cases? Not always. In some cases, there is no need for PRP. However, in the majority of cases, application of PRP to the graft will increase the final amount of bone present in addition to making the wound heal faster and more efficiently.
Can PRP be used alone to stimulate bone formation? No. PRP must be mixed with either your own bone, a bone substitute material such as Puros or Miner Oss , or a synthetic bone product, such as Pep Gen P-15.
Are there any contraindications to PRP? Very few. Obviously, patients with bleeding disorders or hematologic diseases do not qualify for this in-office procedure. Check with Drs. Fraser and Michaels and/or your primary care physician to determine if PRP is right for you.
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Address: 823 North Columbus Street • Lancaster, OH 43130 • Phone: (740) 654-6628
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